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KMID : 0362120030250010089
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Journal of Technologic Dentistry
2003 Volume.25 No. 1 p.89 ~ p.94
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A study on cytotoxicity of Ti-Nb alloys
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Park Hyo-Byeong
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Abstract
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The use of titanium alloys as biomaterials is increasing due to their superior biocompatibility andenhanced corrosion resistance compared to conventional stainless steels and cobalt-based alloys.Ti-6Al-4V (+type) alloy instead of pure titanium (type) is being widely used as biomaterialshas some characteristics such as high fatigue strength, tensile strength and corrosion resistance. Italso has similar characteristics to Ti in inducing bony ingrowth. But it has been reported recentlythat the vanadium element expresses cytotoxicity and carcinogenicity and the aluminium element isrelated with dementia of Alzheimer type and neurotoxicity. In order to overcome their detrimentaleffects, -phase stabilizer Nb was chosen in the present study. CP-Ti(ASTM grade 2), Ti-3wt.%Nb(type), Ti-20wt.%Nb (+type) and Ti-40 wt.%Nb(type)alloys were melted by vacuum arc furnace. Biocompatibility of Ti-Nb alloys was evaluated bycytotoxicity test.The results can be summarized as follows:1. For the cytotoxicity test, Ti-Nb alloys showed excellent biocompatibility compared to CPTi(ASTM grade 2), 316L STS and Co-Cr alloys.
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KEYWORD
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Ti, Nb, Ti-Nb, Cytotoxicity
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